LAUSR

High blood pressure facilitates the progression of arteriosclerosis that increases the incidence of cardiovascular diseases, such as stroke and coronary heart disease. Hypertension is also a major risk factor for the development of cardiovascular organ damages, such as heart failure and renal dysfunction. Considering that the population of elderly people at high risks for cardiovascular events is globally growing, adequate control of blood pressure is of primary importance in order to prevent cardiovascular disorders and elongate the healthy life prognosis. Regarding the relationship between the blood pressure level and the cardiovascular risk, there is not an apparent threshold level from which higher blood pressure is associated with the increase in cardiovascular diseases. Metaanalysis of prospective observational studies has indicated that the risk of cardiovascular diseases, such as stroke and myocardial infarction, increase with increasing blood pressure level and this relationship can be extended even in the normal blood pressure range down to 115/75 mmHg [1]. In addition, the Systolic Blood Pressure Intervention Trial showed that the intensive treatment in high-risk hypertensive patients with target SBP <120 mmHg reduced the rates of cardiovascular events and death as compared with the standard treatment group targeted <140 mmHg [2]. With these backgrounds, the American guideline for the management of high blood pressure (ACC/AHA2017) has lowered the definition level of hypertension to 130/ 80 mmHg or higher [3]. However, the evidence by randomized controlled trials is not necessarily sufficient as to the benefit of targeting this blood pressure level in antihypertensive drug therapy of low to moderate risk hypertensive patients [4]. Therefore, the following European (ESC/ESH2018) and Japanese (JSH2019) guidelines for the management of hypertension [5, 6] have inherited the diagnostic criteria of hypertension as 140/90 mmHg or higher. In these three guidelines, initiation or reinforcement of lifestyle modification is recommended to subjects with 130–139/80–89 mmHg blood level because it costs much less and causes less adverse effects than drug therapy. Even in patients on antihypertensive medication, the reinforcement of lifestyle modification is expected to augment the hypotensive effects of drugs and to reduce the number and doses of antihypertensive drugs. Accordingly, the importance of lifestyle modification is emphasized at this time in the management of hypertensive patients. Table 1 lists the items of lifestyle modification indicated by the Japanese JSH2019 guideline [6]. In the practical treatment of hypertensive patients, comprehensive instruction of multiple lifestyle modifications is more effective than each item alone. Moreover, these approaches are effective not only in lowering blood pressure but also in