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Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections

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The use of natural substance to ward off microbial infections has a long history. However, the large-scale production of natural extracts often reduces antibacterial potency, thus limiting practical applications. Here… Click to show full abstract

The use of natural substance to ward off microbial infections has a long history. However, the large-scale production of natural extracts often reduces antibacterial potency, thus limiting practical applications. Here we present a strategy for converting natural organosulfur compounds into nano-iron sulfides that exhibit enhanced antibacterial activity. We show that compared to garlic-derived organosulfur compounds nano-iron sulfides exhibit an over 500-fold increase in antibacterial efficacy to kill several pathogenic and drug-resistant bacteria. Furthermore, our analysis reveals that hydrogen polysulfanes released from nano-iron sulfides possess potent bactericidal activity and the release of polysulfanes can be accelerated by the enzyme-like activity of nano-iron sulfides. Finally, we demonstrate that topical applications of nano-iron sulfides can effectively disrupt pathogenic biofilms on human teeth and accelerate infected-wound healing. Together, our approach to convert organosulfur compounds into inorganic polysulfides potentially provides an antibacterial alternative to combat bacterial infections.Garlic has a mild antibacterial activity due to its organosulfur content. Here, the authors develop an approach to convert natural organosulfur into iron-sulfur nanosheets, with significantly higher antibacterial activity that can be used against infections as well as biofilms.

Keywords: compounds inorganic; iron sulfides; organosulfur compounds; nano iron; iron; activity

Journal Title: Nature Communications
Year Published: 2018

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