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The unfolded protein response (UPR) regulates cell metabolism and survival in response to stress, yet how the UPR is connected to other signalling pathways is poorly understood. PERK is now… Click to show full abstract
The unfolded protein response (UPR) regulates cell metabolism and survival in response to stress, yet how the UPR is connected to other signalling pathways is poorly understood. PERK is now shown to regulate Bmal1 and Clock proteins to promote cancer cell survival, revealing a link between growth regulation and circadian rhythms.
Keywords:
clock protein;
stress;
links clock;
cancer;
protein stress;
perk links
Journal Title: Nature Cell Biology
Year Published: 2017
Link to full text (if available)
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Journal Title: Nature Cell Biology
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!