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Mechanical signals regulate TORC2 activity

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Maintaining plasma membrane tension is important for eukaryotic cells. How altered membrane tension is sensed and relayed to downstream factors, such as the target of rapamyin complex 2 (TORC2), is… Click to show full abstract

Maintaining plasma membrane tension is important for eukaryotic cells. How altered membrane tension is sensed and relayed to downstream factors, such as the target of rapamyin complex 2 (TORC2), is poorly understood. Reorganization of a signalling lipid into discrete membrane domains is now shown to inactivate TORC2 in yeast.

Keywords: regulate torc2; mechanical signals; signals regulate; membrane; torc2 activity

Journal Title: Nature Cell Biology
Year Published: 2018

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