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The molecular and functional characterization of single cells at scale has emerged as a key driver to unravel tissue biology. Thus, it is important to understand the strengths and limitations… Click to show full abstract
The molecular and functional characterization of single cells at scale has emerged as a key driver to unravel tissue biology. Thus, it is important to understand the strengths and limitations of transcriptomic approaches, molecular barcoding and functional assays used to study cellular properties at the single-cell level. Here, we review recent relevant work from the haematopoietic system and discuss how to interpret and integrate data obtained with different technologies.Jacobsen and Nerlov discuss the complexity, benefits and intrinsic limitations of studying haematopoiesis at the single-cell level using established and emerging technologies.
Journal Title: Nature Cell Biology
Year Published: 2019
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