Photo by nci from unsplash
Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey… Click to show full abstract
Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment. Here, we review recent work on the molecular mechanisms by which ‘epigenetic’ information is transmitted between generations over different timescales, and the importance of this information for development and physiology.Perez and Lehner summarize recent discoveries regarding epigenetic inheritance across generations and review the molecular mechanisms underlying non-DNA sequence-based transmissions.
Journal Title: Nature Cell Biology
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!