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Rivadeneira et al. show that treatment of melanoma-bearing mice with the oncolytic Vaccinia virus recruits metabolically dysfunctional CD8+ T cells, which limits tumour regression. Vaccinia-mediated engineered expression of leptin in… Click to show full abstract
Rivadeneira et al. show that treatment of melanoma-bearing mice with the oncolytic Vaccinia virus recruits metabolically dysfunctional CD8+ T cells, which limits tumour regression. Vaccinia-mediated engineered expression of leptin in cancer cells improved responses through metabolic reprogramming of T cells.
Keywords:
boosts cell;
function tumours;
leptin boosts;
cell function
Journal Title: Nature Reviews Cancer
Year Published: 2019
Link to full text (if available)
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Journal Title: Nature Reviews Cancer
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!