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PDGF pathway in LMNA-related dilated cardiomyopathy

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Activation of the PDGF pathway is involved in the pathogenesis of dilated cardiomyopathy caused by mutations in LMNA; this new finding suggests that inhibition of PDGFRβ is a novel therapeutic… Click to show full abstract

Activation of the PDGF pathway is involved in the pathogenesis of dilated cardiomyopathy caused by mutations in LMNA; this new finding suggests that inhibition of PDGFRβ is a novel therapeutic target for patients with this condition.

Keywords: cardiology; lmna related; pathway lmna; pdgf pathway; dilated cardiomyopathy; related dilated

Journal Title: Nature Reviews Cardiology
Year Published: 2019

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