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Assessing hypertension therapies: randomization or confounding by indication?

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Findings from a large, international study comprising 4.9 million people with mild hypertension suggest that thiazide and thiazide-like diuretics might be more effective and safer than other first-line antihypertensive drugs.… Click to show full abstract

Findings from a large, international study comprising 4.9 million people with mild hypertension suggest that thiazide and thiazide-like diuretics might be more effective and safer than other first-line antihypertensive drugs. However, the study was not randomized, and the findings might be explained by a phenomenon known as ‘confounding by indication’.

Keywords: confounding indication; hypertension therapies; hypertension; therapies randomization; assessing hypertension

Journal Title: Nature Reviews Cardiology
Year Published: 2019

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