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MicroRNA directly modulates cardiac ion channel

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A novel binding mechanism between a microRNA and an inward-rectifier potassium channel has been discovered. MiR-1 directly modulates the function of Kir2.1 to maintain cardiac homeostasis, and disruption to this… Click to show full abstract

A novel binding mechanism between a microRNA and an inward-rectifier potassium channel has been discovered. MiR-1 directly modulates the function of Kir2.1 to maintain cardiac homeostasis, and disruption to this relationship predisposes the heart to a greater risk of arrhythmogenesis.

Keywords: modulates cardiac; ion channel; microrna directly; channel; directly modulates; cardiac ion

Journal Title: Nature Reviews Cardiology
Year Published: 2021

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