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Non-fatal MI as surrogate end point for all-cause or cardiovascular mortality

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In a pooled analysis of 144 high-quality randomized trials involving patients with coronary artery disease, application of the most stringent criteria for surrogacy demonstrated that a reduction in the rates… Click to show full abstract

In a pooled analysis of 144 high-quality randomized trials involving patients with coronary artery disease, application of the most stringent criteria for surrogacy demonstrated that a reduction in the rates of non-fatal myocardial infarction by any intervention did not necessarily predict a reduction in all-cause or cardiovascular mortality during follow-up.

Keywords: fatal surrogate; cardiovascular mortality; non fatal; cause cardiovascular

Journal Title: Nature Reviews Cardiology
Year Published: 2022

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