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The future of cardiac xenotransplantation

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Reflecting on the first genetically engineered pig-to-human heart transplantation in this Clinical Outlook article, we discuss the likely future of cardiac xenotransplantation. Initial clinical trials are expected to explore compassionate… Click to show full abstract

Reflecting on the first genetically engineered pig-to-human heart transplantation in this Clinical Outlook article, we discuss the likely future of cardiac xenotransplantation. Initial clinical trials are expected to explore compassionate use as destination therapy in carefully selected adult patients and as a bridge to heart allotransplantation in infant patients with complex congenital heart disease.

Keywords: future cardiac; cardiac xenotransplantation; cardiology; heart

Journal Title: Nature Reviews Cardiology
Year Published: 2022

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