LAUSR

Poly(ADPribose) polymerase (PARP) inhibitors have been previously shown to improve the outcomes of patients with BRCAmutant prostate cancer. Now, data from a phase II study demonstrate that the PARP inhibitor olaparib, in combination with abiraterone, provides benefit even in the absence of homologous recombination (HRR) deficiency. 142 patients were randomly assigned to receive abiraterone plus olaparib or abiraterone plus placebo regardless of HRR status. Patients receiving olaparib plus abiraterone had significantly improved median radiographic progressionfree survival relative to those in the abiraterone plus placebo group (13.8 months versus 8.2 months; HR 0.65, 95% CI 0.44–0.97; P = 0.034). Patients in the olaparib group had an increased risk of grade ≥3 adverse events (41% versus 27%); however, grade 1–2 adverse events were more frequent in patients receiving abiraterone alone.