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Translating noninvasive molecular responses into clinical reality for cancer immunotherapy

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Noninvasive liquid biopsy assays integrating tumour and immune biomarkers are a promising tool to enhance clinical decision-making in immuno-oncology. Here, we discuss how circulating tumour DNA dynamics, in conjunction with… Click to show full abstract

Noninvasive liquid biopsy assays integrating tumour and immune biomarkers are a promising tool to enhance clinical decision-making in immuno-oncology. Here, we discuss how circulating tumour DNA dynamics, in conjunction with pre-treatment tumour and immune features, can predict clinical response to immune-checkpoint inhibitors alongside the challenges in making their use a clinical reality.

Keywords: clinical reality; molecular responses; translating noninvasive; noninvasive molecular; oncology

Journal Title: Nature Reviews Clinical Oncology
Year Published: 2020

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