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Genesis, genes and epigenetics of endometriosis-associated infertility

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Jae-Wook Jeong and colleagues report that histone deacetylase 3 (HDAC3) is downregulated in the endometrium of women with endometriosis. In addition, they show that the loss of HDAC3 is associated… Click to show full abstract

Jae-Wook Jeong and colleagues report that histone deacetylase 3 (HDAC3) is downregulated in the endometrium of women with endometriosis. In addition, they show that the loss of HDAC3 is associated with aberrant hormonal signalling and increased fibrosis in the endometrium and impaired endometrial receptivity.

Keywords: epigenetics endometriosis; endometriosis associated; genesis genes; genes epigenetics; associated infertility

Journal Title: Nature Reviews Endocrinology
Year Published: 2019

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