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Negative regulator of GDF15 signalling identified

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0123456789();: Nature reviews | Endocrinology Original article Chow, C. F. W. et al. Body weight regulation via MT1-MMP-mediated cleavage of GFRAL. Nat. Metab. https://doi.org/ 10.1038/s42255-022-00529-5 related articles Wang, D. et… Click to show full abstract

0123456789();: Nature reviews | Endocrinology Original article Chow, C. F. W. et al. Body weight regulation via MT1-MMP-mediated cleavage of GFRAL. Nat. Metab. https://doi.org/ 10.1038/s42255-022-00529-5 related articles Wang, D. et al. GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease. Nat. Rev. Endocrinol. 17, 592–607 (2021) MT1-MMP knockout in GFRAL+ neurons potentiated GDF15– GFRAL signalling

Keywords: regulator gdf15; signalling identified; gdf15 signalling; negative regulator; endocrinology; biology

Journal Title: Nature Reviews Endocrinology
Year Published: 2022

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