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Cytosine base editors go off-target

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Two studies in Science show that cytosine base editors, but not adenine base editors or CRISPR–Cas9, induce notable off-target single-nucleotide variants in rice and in mouse embryos. Click to show full abstract

Two studies in Science show that cytosine base editors, but not adenine base editors or CRISPR–Cas9, induce notable off-target single-nucleotide variants in rice and in mouse embryos.

Keywords: editors target; base editors; base; cytosine base

Journal Title: Nature Reviews Genetics
Year Published: 2019

Link to full text (if available)


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