Photo by nci from unsplash
Identifying factors bound to specific genomic loci in an unbiased manner is the holy grail of chromatin research, because it would provide an ultimate description of locus function. In this… Click to show full abstract
Identifying factors bound to specific genomic loci in an unbiased manner is the holy grail of chromatin research, because it would provide an ultimate description of locus function. In this Comment, we explain why purifying a single locus represents a major technical challenge and provide recommendations for achieving this goal. Michiel Vermeulen and Jérôme Déjardin recommend how best to characterize the proteins that bind any specific genomic locus.
Keywords:
chromatin isolation;
chromatin;
locus specific;
specific chromatin;
biology;
locus
Journal Title: Nature Reviews Molecular Cell Biology
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Nature Reviews Molecular Cell Biology
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!