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Whether adult humans continue to produce new neurons remains controversial. Here, Durante et al. sampled olfactory neuroepithelium from seven healthy middle-aged people, and used single-cell RNA sequencing and immunohistochemistry to… Click to show full abstract
Whether adult humans continue to produce new neurons remains controversial. Here, Durante et al. sampled olfactory neuroepithelium from seven healthy middle-aged people, and used single-cell RNA sequencing and immunohistochemistry to determine cellular heterogeneity and maturation stage. They observed cells from all stages of differentiation, from stem cells to mature neurons, with a surprisingly high 55% of the cells expressing immature markers. These data suggest that the olfactory neuroepithelium is a site of ongoing neurogenesis in adult humans.
Journal Title: Nature Reviews Neuroscience
Year Published: 2020
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