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from patients with OA compared with undamaged control cartilage. Furthermore, in the destabilization of the medial meniscus mouse model of OA, intra-articular adenoviral delivery of Itgbl1 reduced cartilage damage and… Click to show full abstract
from patients with OA compared with undamaged control cartilage. Furthermore, in the destabilization of the medial meniscus mouse model of OA, intra-articular adenoviral delivery of Itgbl1 reduced cartilage damage and osteophyte formation. “As a long-term goal, we are trying to identify the minimal domain of ITGBL1 that could be used to treat various integrin-mediated diseases,” states Park. “Ultimately, we hope to develop peptide drugs based on the ITGBL1 sequence.” Joanna Collison
Keywords:
oligonucleotide therapy;
antisense oligonucleotide;
new antisense
Journal Title: Nature Reviews Rheumatology
Year Published: 2018
Link to full text (if available)
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Journal Title: Nature Reviews Rheumatology
Year Published: 2018
Link to full text (if available)
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recommendations!