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Revisiting 5α-reductase inhibitors and the risk of prostate cancer

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The role of 5α-reductase inhibitors (5-ARI) in prostate cancer chemoprevention remains a controversy, as cancer prevention trials with 5-ARIs have shown a decreased incidence of low-grade prostate cancer but a… Click to show full abstract

The role of 5α-reductase inhibitors (5-ARI) in prostate cancer chemoprevention remains a controversy, as cancer prevention trials with 5-ARIs have shown a decreased incidence of low-grade prostate cancer but a potential increased risk in high-grade disease. Recent studies have shed light on the long-term safety of 5-ARIs in terms of influencing prostate cancer risk.

Keywords: cancer; reductase inhibitors; prostate cancer; revisiting reductase

Journal Title: Nature Reviews Urology
Year Published: 2018

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