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The triplet code underpins analyses of rare and de novo mutations in exome sequencing data, but analysis of the noncoding genome is much more challenging. A new analytical framework for… Click to show full abstract
The triplet code underpins analyses of rare and de novo mutations in exome sequencing data, but analysis of the noncoding genome is much more challenging. A new analytical framework for common, complex diseases highlights the need for very large samples to overcome the unavoidable multiple-testing burden and hence provides preemptive warnings against underpowered studies.
Keywords:
studies common;
whole genome;
common diseases;
sizing whole;
sequencing studies;
genome sequencing
Journal Title: Nature Genetics
Year Published: 2018
Link to full text (if available)
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Journal Title: Nature Genetics
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!