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Pachytene piRNAs as beneficial regulators or a defense system gone rogue

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Pachytene Piwi-interacting RNAs (piRNAs) are abundant small non-coding RNAs expressed in mammalian germ lines. A new study indicates that, among the diverse pool of piRNA sequences, a small number act… Click to show full abstract

Pachytene Piwi-interacting RNAs (piRNAs) are abundant small non-coding RNAs expressed in mammalian germ lines. A new study indicates that, among the diverse pool of piRNA sequences, a small number act as highly selective guides that induce cleavage of coding and non-coding transcripts, thus promoting piRNA generation and regulating gene expression.

Keywords: beneficial regulators; system gone; pirnas beneficial; pachytene pirnas; defense system; regulators defense

Journal Title: Nature Genetics
Year Published: 2020

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