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Understanding the Pro/N-end rule pathway

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Regulated destruction of proteins underlies just about everything a cell does. A structural study of human Gid4, the N-recognin of the Pro/N-end rule pathway that targets proteins through their N-terminal… Click to show full abstract

Regulated destruction of proteins underlies just about everything a cell does. A structural study of human Gid4, the N-recognin of the Pro/N-end rule pathway that targets proteins through their N-terminal proline, illuminates the recognition of substrates by this proteolytic system.

Keywords: understanding pro; rule pathway; end rule; pro end

Journal Title: Nature Chemical Biology
Year Published: 2018

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