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Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4 DCAF15 broaden the… Click to show full abstract
Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4 DCAF15 broaden the mechanistic principles by which molecular glues target ubiquitylation.
Keywords:
concept solidifies;
molecular glue;
glue concept;
biology;
glue
Journal Title: Nature Chemical Biology
Year Published: 2019
Link to full text (if available)
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Journal Title: Nature Chemical Biology
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!