LAUSR

Escherichia coli are a common component of the human microbiota, and isolates exhibit probiotic, commensal and pathogenic roles in the host. E. coli members often use diverse small molecule chemistry to regulate intrabacterial, intermicrobial and host–bacterial interactions. While E. coli are considered to be a well-studied model organism in biology, much of their chemical arsenal has only more recently been defined, and much remains to be explored. Here we describe chemical signaling systems in E. coli in the context of the broader field of metabolism at the host–bacteria interface and the role of this signaling in disease modulation. Escherichia coli are a common component of the human microbiota, producing a diverse collection of small molecules that regulate intra- and interspecies interactions, including those with other microorganisms and with the host.