LAUSR

Protection from harmful pathogens depends on activation of the immune system, which relies on tight regulation of gene expression. Recently, the RNA modification N6-methyladenosine (m6A) has been found to play an essential role in such regulation. Here, we summarize newly discovered functions of m6A in controlling various aspects of immunity, including immune recognition, activation of innate and adaptive immune responses, and cell fate decisions. We then discuss some of the current challenges in the field and describe future directions for uncovering the immunological functions of m6A and its mechanisms of action. The RNA modification N6-methyladenosine (m6A) plays an essential role in the regulation of immunity. Here, Shulman and Stern-Ginossar review the roles of m6A in controlling immune recognition, activation of innate and adaptive immune responses, and cell fate decisions.