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Sensitive protein alignments at tree-of-life scale using DIAMOND

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We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new… Click to show full abstract

We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.

Keywords: protein alignments; life scale; diamond; tree life

Journal Title: Nature Methods
Year Published: 2021

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