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Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions

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This study described an efficient and practical approach for amide synthesis. The reaction was conducted under metal- and solvent-free conditions at a mild temperature (40 °C) in air, and readily available… Click to show full abstract

This study described an efficient and practical approach for amide synthesis. The reaction was conducted under metal- and solvent-free conditions at a mild temperature (40 °C) in air, and readily available formamides were used as an amino source. This reaction can be easily upgraded to the gram level with an excellent yield.

Keywords: metal solvent; solvent free; free synthesis; amino source

Journal Title: Scientific Reports
Year Published: 2019

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