Photo by shalone86 from unsplash
Discovery of protein modification sites relies on protein digestion by proteases and mass spectrometry (MS) identification of the modified peptides. Depending on proteases used and target protein sequence, this method… Click to show full abstract
Discovery of protein modification sites relies on protein digestion by proteases and mass spectrometry (MS) identification of the modified peptides. Depending on proteases used and target protein sequence, this method yields highly variable coverage of modification sites. We introduce PTMselect, a digestion-simulating software which tailors the optimal set of proteases for discovery of global or targeted modification from any single or multiple proteins.
Keywords:
protein;
mass spectrometry;
ptmselect optimization;
optimization protein;
protein modifications
Journal Title: Scientific Reports
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Scientific Reports
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!