LAUSR

This analysis investigated the age- and BMI-related variations of fat distribution in sacral and lumbar bone marrow and their association with local muscle fat content in order to detect fat distribution patterns and variations in healthy adults using proton density fat fraction (PDFF) measurements. A six-echo 3D spoiled gradient-echo sequence was used for chemical shift encoding-based water-fat separation at the sacral and lower lumbar region in 103 healthy volunteers. PDFF values of the sacrum, 5 th lumbar vertebral body, the gluteal and paraspinal muscles were determined. Correlation with age was significant ( p  < 0.05) for PDFF of the sacrum (men (m): r  = 0.58; women (w): r  = 0.54), L5 (m: r  = 0.58; w: r  = 0.54), the gluteal (m: r  = 0.51; w: r  = 0.44) and paraspinal (m: r  = 0.36; w: r  = 0.49) muscles in both genders. BMI correlated significantly with the paraspinal musculature in men ( r  = 0.46) and women ( r  = 0.33). Correlation testing revealed significant correlations ( p  < 0.05) between the two osseous (m: r  = 0.63, w: r  = 0.75) and the muscle compartments (m: r  = 0.63, w: r  = 0.33) in both genders. Bone marrow and muscle fat infiltration patterns were not significantly associated with each other at the sacral and lower lumbar spine region. The presented data suggest that the two compartments may have distinct pathophysiological fat infiltration patterns. However, further clinical studies are needed to support the results.