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Modular barcode beads for microfluidic single cell genomics

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Barcode beads allow efficient nucleic acid tagging in single cell genomics. Current barcode designs, however, are fabricated with a particular application in mind. Repurposing to novel targets, or altering to… Click to show full abstract

Barcode beads allow efficient nucleic acid tagging in single cell genomics. Current barcode designs, however, are fabricated with a particular application in mind. Repurposing to novel targets, or altering to add additional targets as information is obtained is possible but the result is suboptimal. Here, we describe a modular framework that simplifies generation of multifunctional beads and allows their easy extension to new targets.

Keywords: single cell; barcode; barcode beads; cell genomics; modular barcode

Journal Title: Scientific Reports
Year Published: 2021

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