LAUSR

This study aimed to evaluate the predictive value of metabolic parameters in preoperative non-enhancing peritumoral regions (NEPTRs) for glioblastoma recurrence, using multivoxel hydrogen proton magnetic resonance spectroscopy (1H-MRS). Clinical and imaging data from patients with recurrent glioblastoma were analyzed. Through co-registration of preoperative and post-recurrence MRI, we identified future tumor recurrence regions (FTRRs) and future non-tumor recurrence regions (FNTRRs) within the NEPTRs. Metabolic parameters were recorded separately for each region. Cox regression analysis was applied to assess the association between metabolic parameters and glioblastoma recurrence. Compared to FNTRRs, FTRRs exhibited a higher Cho/Cr ratio, higher Cho/NAA ratio, and lower NAA/Cr ratio. Both Cho/NAA and Cho/Cr ratios were recognized as risk factors in univariate and multivariate analyses (P < 0.05). The Cox regression model indicated that Cho/NAA > 1.99 and Cho/Cr > 1.73 are independent risk factors for early glioblastoma recurrence. Based on these cut-off values, patients were stratified into low-risk and high-risk groups, with a statistically significant difference in recurrence rates between the two groups (P < 0.01). The Cho/NAA and Cho/Cr ratios in NEPTRs are independent predictors of future glioblastoma recurrence. Specifically, Cho/NAA > 1.99 and/or Cho/Cr > 1.73 in NEPTRs may indicate a higher risk of early postoperative recurrence at these regions.