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Addendum: The effect of early life experience, environment, and genetic factors on spontaneous home-cage aggression-related wounding in male C57BL/6 mice

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The version of this article originally published contained an error in the calculation of the weighted PALS score. In the Excel worksheet used for scoring the images (Supplementary Data), an… Click to show full abstract

The version of this article originally published contained an error in the calculation of the weighted PALS score. In the Excel worksheet used for scoring the images (Supplementary Data), an error was made whereby the weighted section score was calculated as ‘lesion score/proportion’, whereas it should have been calculated as ‘lesion score × proportion’. This miscalculation occurred in 82 of the total 2,700 sections that were scored, and affected the final PALS scores. To correct this error, the authors have revised Figs. 1–6 to reflect the corrected least square mean weighted PALS and associated variances, and amended the Results section to provide the revised GLM and P values. The corrections in the statistical tests did not change the significance of any of the findings. In addition, in the “Substrain” subsection under “Statistical analyses” in the Materials and Methods section, the opening text should have read as follows: “A full factorial GLM was run and included the following factors: substrain of B6 and ID method, plus their interaction. The interaction of the two factors was not significant, so it was removed from the final analysis, which tested only the two main effects.” Corrected figures, Results, and Supplementary Data are included in this Addendum; the original article and associated Supplementary Information published online have not been revised.

Keywords: environment genetic; addendum effect; early life; life experience; experience environment; effect early

Journal Title: Lab Animal
Year Published: 2019

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