LAUSR

Lab animaL | VOL 48 | OCTOBER 2019 | 275–277 | www.nature.com/laban terms of relative replacement (described in The Guide3), I don’t want to proceed with the NHP studies until I have learned all I can from my canine work. The next amendment I submit will be to add the additional animal numbers and tests I need to further elucidate the cause of the mild toxicity observed. Lastly, the Animal Welfare Act4 authorizes the Secretary of Agriculture of the United States or his representative to promulgate humane handling, care and treatment of animals at research facilities, but it does not authorize the Secretary to promulgate rules, regulations, or orders with regard to the design, outlines, or guidelines of actual research or experimentation by a research facility. Additionally, the U.S. Senate has a code of official conduct that the senator may have violated with his actions. The senator himself has no authority to determine the course of the research. ❐