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Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance

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Recently, three groups independently identified ubiquitin-specific peptidase 21 (USP21) as an efficient deubiquitylase that reverses Nanog polyubiquitylation and stabilizes Nanog protein. In this preview, I have summarized the work of… Click to show full abstract

Recently, three groups independently identified ubiquitin-specific peptidase 21 (USP21) as an efficient deubiquitylase that reverses Nanog polyubiquitylation and stabilizes Nanog protein. In this preview, I have summarized the work of these three groups.

Keywords: nanog novel; role usp21; novel role; deubiquitylating nanog; usp21 embryonic; embryonic stem

Journal Title: Signal Transduction and Targeted Therapy
Year Published: 2017

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