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An I2-promoted formal [3+2] cycloaddition for access to oxazoles has been demonstrated. This is the first example of a Lewis acid-promoted formal [3+2] cycloaddition of isocyanides with methyl ketones involving… Click to show full abstract
An I2-promoted formal [3+2] cycloaddition for access to oxazoles has been demonstrated. This is the first example of a Lewis acid-promoted formal [3+2] cycloaddition of isocyanides with methyl ketones involving the C[triple bond, length as m-dash]N cleavage of isocyanides. The salient feature of this approach is unconventional 2,5-disubstituted oxazole formation from isocyanides and ketones rather than 4,5-substituted oxazoline.
Keywords:
methyl ketones;
cycloaddition methylenyl;
promoted formal;
formal cycloaddition;
isocyanides methyl
Journal Title: Chemical communications
Year Published: 2017
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!