A simple and convenient method for the construction of substituted cycloheptenones from 1-bromoocta-1,7-diene-3-ols has been developed. The reaction involves Pd(0)-catalyzed intramolecular 7-exo-trig cyclization followed by Pd(II)-catalyzed oxidation of cyclic alcohol.… Click to show full abstract
A simple and convenient method for the construction of substituted cycloheptenones from 1-bromoocta-1,7-diene-3-ols has been developed. The reaction involves Pd(0)-catalyzed intramolecular 7-exo-trig cyclization followed by Pd(II)-catalyzed oxidation of cyclic alcohol. The course of the reaction pathway has been evaluated using DFT calculations.
Keywords:
oxidation;
cyclization;
intramolecular sequential;
sequential heck;
evaluated using;
catalyzed intramolecular
Journal Title: New Journal of Chemistry
Year Published: 2017
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Journal Title: New Journal of Chemistry
Year Published: 2017
Link to full text (if available)
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recommendations!