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A combinative C2-selective arylation, and C3-selective carbonylation of free indole derivatives, by means of TEMPO catalysis and a silver oxidant under non-directing group conditions, was successful demonstrated. This new methodology… Click to show full abstract
A combinative C2-selective arylation, and C3-selective carbonylation of free indole derivatives, by means of TEMPO catalysis and a silver oxidant under non-directing group conditions, was successful demonstrated. This new methodology is both atom and step efficient and is applicable to a broad scope of substrates, allowing the synthesis of a range of synthetically valuable 3,2′-biindolin-2-ones in moderate to excellent yields.
Keywords:
biindolin;
biindolin ones;
homocoupling route;
tempo catalyzed;
oxidative homocoupling;
catalyzed oxidative
Journal Title: RSC Advances
Year Published: 2017
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Journal Title: RSC Advances
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!