Achieving the combination of real-time diagnosis and therapy in one up-converting platform with sensitive thermometry and efficient heat production is a critical step towards photo-thermal therapy (PTT). Here, the potentiality… Click to show full abstract
Achieving the combination of real-time diagnosis and therapy in one up-converting platform with sensitive thermometry and efficient heat production is a critical step towards photo-thermal therapy (PTT). Here, the potentiality of truncated octahedral YF3:Tm3+/Yb3+ micro-crystals as thermometers operating in the first biological window (BW-I) was evaluated on the basis of a thermo-responsive fluorescence intensity ratio (FIR) of far-red to NIR emission from completely separated 3F2,3/3H4 → 3H6 transitions. The probabilities of cross-relaxation (CR) processes related to 3F2,3/3H4 levels were greatly enhanced by increasing the Yb3+ content, leading to an increase of more than three times in the absolute sensitivity within the physiological temperature range. Photo-thermal effects were also assessed by monitoring the variation of temperature around the samples as functions of the Yb3+ dosage, excitation time and density of 980 nm laser diodes. These results offer a promising strategy to optimize the thermal sensitivity and optical heating ability, which indicates that the present UC platform has great potential applications in PTT as real-time thermometers and photo-thermal agents.
               
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