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Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles.

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Multifunctional low-generation dendrimer-entrapped gold nanoparticles (Au DENPs) were designed and synthesized. The formed Au DENPs modified with an arginine-glycine-aspartic peptide and labeled with 99mTc possess a uniform size distribution, desirable… Click to show full abstract

Multifunctional low-generation dendrimer-entrapped gold nanoparticles (Au DENPs) were designed and synthesized. The formed Au DENPs modified with an arginine-glycine-aspartic peptide and labeled with 99mTc possess a uniform size distribution, desirable colloidal stability and biocompatibility, and can be used as a promising nanoprobe for targeted SPECT/CT imaging of αvβ3 integrin-expressing tumors.

Keywords: gold nanoparticles; entrapped gold; low generation; dendrimer entrapped; generation dendrimer

Journal Title: Biomaterials science
Year Published: 2017

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