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Multiplexed gene silencing in living cells and in vivo using a DNAzymes-CoOOH nanocomposite.

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We demonstrate a novel DNAzymes-based nanocomposite that can simultaneously silence three types of genes in living cells and in vivo. The synergetic strategy for silencing three different genes can significantly… Click to show full abstract

We demonstrate a novel DNAzymes-based nanocomposite that can simultaneously silence three types of genes in living cells and in vivo. The synergetic strategy for silencing three different genes can significantly enhance the knockdown efficacy and effectively inhibit the cancer cells' progression.

Keywords: cells vivo; vivo using; multiplexed gene; gene silencing; living cells; silencing living

Journal Title: Chemical communications
Year Published: 2017

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