(NHC)-Cu-catalyzed C(sp)-C(sp3) bond formation has been successfully achieved under mild conditions. Nonactivated alkyl triflates, which could be easily derived from alcohols, were utilized as C-O electrophiles. Mechanistic studies suggested that… Click to show full abstract
(NHC)-Cu-catalyzed C(sp)-C(sp3) bond formation has been successfully achieved under mild conditions. Nonactivated alkyl triflates, which could be easily derived from alcohols, were utilized as C-O electrophiles. Mechanistic studies suggested that copper acetylide was the active species. Scale-up reactions further demonstrated the practicality and efficiency of the developed strategy.
Keywords:
carbene copper;
alkyl triflates;
copper;
catalyzed direct;
copper catalyzed;
heterocyclic carbene
Journal Title: Chemical communications
Year Published: 2017
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Journal Title: Chemical communications
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!