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Phase-transfer catalyzed asymmetric synthesis of α,β-unsaturated γ,γ-disubstituted γ-lactams.

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The direct enantioselective vinylogous Michael addition of unsaturated γ-monosubstituted γ-lactams was realized by using chiral phase-transfer catalysis as a means to give enantioenriched γ,γ-disubstituted γ-lactams. Click to show full abstract

The direct enantioselective vinylogous Michael addition of unsaturated γ-monosubstituted γ-lactams was realized by using chiral phase-transfer catalysis as a means to give enantioenriched γ,γ-disubstituted γ-lactams.

Keywords: catalyzed asymmetric; transfer catalyzed; phase transfer; synthesis unsaturated; asymmetric synthesis; disubstituted lactams

Journal Title: Chemical communications
Year Published: 2017

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