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Direct catalytic enantioselective Mannich-type reaction of α,α-dithioacetonitriles with imines using chiral bis(imidazoline)-Pd complexes.

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The first highly enantioselective reaction of α,α-dithioacetonitriles with imines has been developed. Good yields and enantioselectivity were observed for the reaction of various imines using chiral bis(imidazoline) catalysts. The obtained… Click to show full abstract

The first highly enantioselective reaction of α,α-dithioacetonitriles with imines has been developed. Good yields and enantioselectivity were observed for the reaction of various imines using chiral bis(imidazoline) catalysts. The obtained products can be converted into β-aminonitrile or 1,3-diaminoketone.

Keywords: reaction dithioacetonitriles; chiral bis; reaction; imines using; dithioacetonitriles imines; using chiral

Journal Title: Chemical communications
Year Published: 2017

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