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A succinct and efficient protocol was developed for the synthesis of chiral aromatic ketones via asymmetric hydrogenation of β,β-disubstituted enones with rhodium catalysts based on chiral bisphosphine thiourea ligands. A… Click to show full abstract
A succinct and efficient protocol was developed for the synthesis of chiral aromatic ketones via asymmetric hydrogenation of β,β-disubstituted enones with rhodium catalysts based on chiral bisphosphine thiourea ligands. A series of substrates (17 examples) was smoothly catalyzed to afford the corresponding chiral aromatic ketones in high conversions (>99%) with excellent enantioselectivities (up to 96% ee).
Keywords:
ketones via;
aromatic ketones;
synthesis chiral;
asymmetric hydrogenation;
chiral aromatic;
hydrogenation disubstituted
Journal Title: Chemical communications
Year Published: 2017
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Journal Title: Chemical communications
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!