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Expeditious synthesis of pyrano[2,3,4-de]quinolines via Rh(iii)-catalyzed cascade C-H activation/annulation/lactonization of quinolin-4-ol with alkynes.

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Rh(iii)-catalyzed cascade C-H activation/annulation/lactonization of quinoline-4-ols and alkynes has been reported. A broad range of tetracyclic pyrano[2,3,4-de]quinolines have been prepared in one-step with good functional group tolerance, excellent site selectivity,… Click to show full abstract

Rh(iii)-catalyzed cascade C-H activation/annulation/lactonization of quinoline-4-ols and alkynes has been reported. A broad range of tetracyclic pyrano[2,3,4-de]quinolines have been prepared in one-step with good functional group tolerance, excellent site selectivity, and high efficiency.

Keywords: annulation lactonization; iii catalyzed; cascade activation; pyrano quinolines; activation annulation; catalyzed cascade

Journal Title: Chemical communications
Year Published: 2017

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