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Copper-catalyzed radical cascade oxyalkylation of olefinic amides with simple alkanes: highly efficient access to benzoxazines.

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A copper-catalyzed C(sp3)-H bond functionalization of simple alkanes with olefinic amides was developed for the efficient synthesis of important benzoxazine derivatives. It involves new C-C and C-O bond formation in… Click to show full abstract

A copper-catalyzed C(sp3)-H bond functionalization of simple alkanes with olefinic amides was developed for the efficient synthesis of important benzoxazine derivatives. It involves new C-C and C-O bond formation in one step via a radical cascade process.

Keywords: radical cascade; catalyzed radical; simple alkanes; copper catalyzed; olefinic amides

Journal Title: Chemical communications
Year Published: 2017

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