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Cysteine and glutathione are able to reduce Cu(ii) coordinated to the peptide amyloidβ4-16, and shuttle the resulting Cu(i) to partially replace Zn(ii) in the protein Zn7-metallothionein-3. The released Zn(ii) in… Click to show full abstract
Cysteine and glutathione are able to reduce Cu(ii) coordinated to the peptide amyloidβ4-16, and shuttle the resulting Cu(i) to partially replace Zn(ii) in the protein Zn7-metallothionein-3. The released Zn(ii) in turn binds to amyloid-β4-16. Thus cysteine and glutathione are modulators of Cu/Zn-distribution between metallothionein-3 and amyloid-β4-16.
Keywords:
zn7 metallothionein;
cysteine glutathione;
trigger swap;
glutathione;
glutathione trigger
Journal Title: Chemical communications
Year Published: 2017
Link to full text (if available)
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Journal Title: Chemical communications
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!