A carbene-catalyzed cascade reaction is developed for the synthesis of multi-substituted indane derivatives. The reaction involves two sequential Michael-addition steps, of which the first step is enabled by an NHC-mediated… Click to show full abstract
A carbene-catalyzed cascade reaction is developed for the synthesis of multi-substituted indane derivatives. The reaction involves two sequential Michael-addition steps, of which the first step is enabled by an NHC-mediated radical process. This work demonstrates the synthetic potentials of NHC-mediated single-electron-transfer processes for efficient reactions and rapid synthesis.
               
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